Antimicrobial resistance, or AMR, is a global health crisis that especially impacts the most vulnerable patient populations. AMR threatens advances made in all aspects of modern medicine including complex surgical procedures, transplantation, and cancer treatment. Annually in the United States, more than two million people become infected with antibiotic-resistant bacteria and more than 23,000 people die each year as a direct result of these infections (www.CDC.gov).
UNC researchers work to better understand AMR through basic science, translational research and clinical investigation.
The Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae — is led by David van Duin, MD, PhD. Since 2011, he has been conducting this prospective, observational, multi-center study that evaluates carbapenem-resistant Enterobacteriaceae (CRE) in hospitalized patients. CRACKLE is federally funded through the Antibacterial Resistance Leadership Group. After the completion of CRACKLE-1, which focused on the Great Lakes area in the US, he initiated CRACKLE-2, an expansion of the first study which covers more than 80 hospitals in 17 states in the US. In addition, international sites, including China and Colombia, are also enrolling patients into CRACKLE-2.
- Antimicrobial resistance after burn injuries and severe skin disorders
- Antimicrobial stewardship (Carolina Antimicrobial Stewardship Program website)
- Carbapenemase-producing Enterobacteriaceae
- Mechanisms of antibiotic resistance in Staphylococcus aureus