David Margolis, MD
Sarah Graham Kenan Distinguished Professor of Medicine, Division of Infectious Diseases
Director, UNC HIV Cure Center, Margolis Lab
Professor of Microbiology and Immunology, and Epidemiology
Principal Investigator, Collaboratory of AIDS Researchers for Eradication (CARE)
Areas of Interest
HIV/AIDS
About
Dr. Margolis’ research group has a long history of translational HIV research: investigating basic molecular, virological, and immunological phenomenon, and leveraging insights to develop new interventions in HIV disease. While his work has involved many aspects of HIV science and medicine, for more than two decades a central focus has been the study of molecular mechanisms of HIV proviral latency and persistence despite potent antiretroviral therapy (ART). They have defined the role of epigenetic factors in the restriction of HIV expression, and this has led to diverse, multidisciplinary collaborations and translational clinical studies resulting in discovery and high-impact work. He is the principal investigator for CARE (Collaboratory of AIDS Researchers for Eradication), an NIH-funded research organization that seeks to develop the tools to bring an HIV cure from the bench to the clinic. He is the principal investigator of NIH-funded studies combining immunotherapies (antibody-like molecules or antiviral T cell infusions) and small-molecule anti-latency agent (HDAC inhibitor) in FDA-approved investigations to attempt to precisely document the depletion of persistent HIV infection. Finally, he directs the UNC HIV Cure Center, created to support novel and impactful research needed to advance towards therapies to induce an HIV remission.
Honors and Awards
- Fellow, American Academy for the Advancement of Science (AAAS), 2022
- Member, Association of American Physicians (AAP), 2019
- Web of Science Highly Cited Researchers, 2019, 2020
- Sarah Graham Kenan Distinguished Professor of Medicine, UNC Chapel Hill, 2018
- Tim Gill Visiting Professor, University of Colorado at Denver, 2013
- M. Glenn Koenig Visiting Professor, Vanderbilt Univ. School of Medicine, 2011
- William J. Way award for HIV medicine, Duke Univ. School of Medicine, 2005
- Member, American Society of Clinical Investigation (ASCI), 2005
- 5th International Workshop on HIV Drug Resistance & Treatment Strategies award, 2001
- Fellow, Infectious Diseases Society of America (IDSA), 1998
- Infectious Diseases Society of America, Ortho-MacNeil Young Investigator, 1997
- National Foundation for Infectious Diseases Young Investigator, 1996
- Fellow, American College of Physicians (ACP), 1996
- NIH Physician-Scientist (K-11) Award, 1991
- Clinical Associates award, American College of Physicians, 1988
- Magna Cum Laude, Harvard College, 1981
Education
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Undergraduate
Harvard College
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Medical School
Tufts University School of Medicine
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Residency
Tufts-New England Medical Center
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Fellowship
University of Massachusetts Medical Center
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Fellowship
National Institutes of Health, National Institute of Allergy & Infectious Diseases