An HIV Cure In 10 Years? Update On Progress and Challenges

David Margolis, MD, is Sarah Graham Kenan Distinguished Professor of Medicine, Professor of Microbiology & Immunology, and Epidemiology, and Director of the UNC HIV Cure Center. His research group has a long history of translational HIV research: investigating basic molecular, virological, and immunological phenomenon, and leveraging insights to develop new interventions in HIV disease.  He is the principal investigator for CARE (Collaboratory of AIDS Researchers for Eradication), an NIH-funded research organization that seeks to develop the tools to bring an HIV cure from the bench to the clinic. He is also the principal investigator of NIH-funded studies combining immunotherapies (antibody-like molecules or antiviral T cell infusions) and small-molecule anti-latency agent (HDAC inhibitor) in FDA-approved investigations to attempt to precisely document the depletion of persistent HIV infection. And, he directs the UNC HIV Cure Center, created to support novel and impactful research needed to advance towards therapies to induce an HIV remission.