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Training Years: 2016-2017

Training Site: Perinatal HIV Research Unit, University of Witwatersrand

Country: South Africa

Mentor: Richard Ambinder, MD; Neil Martinson, MD, MPH

Title: Molecular assessment of Circulating Cell-Free DNA in HIV-infected patients with and without Lymphoma

Project Objectives:  This study proposes to evaluate the detection of clonal Immunoglobulin DNA rearrangements in lymphoma specimens from HIV-infected patients in Johannesburg and Klerksdorp, South Africa.

Aim 1: Molecular assessment of 100 South African AIDS lymphoma biopsy specimens

Aim 2: Molecular assessment of plasma from 100 patients with HIV but without lymphoma.

Aim 3: Molecular assessment of 100 plasma and corresponding diagnostic biopsy specimens from patients with untreated AIDS lymphoma

Aim 4: Molecular assessment of 80 plasma and fine needle aspiration (FNA) specimens from patients with HIV

and TB co-infection

NIH Support:  Fogarty fellowship postdoctoral training award

Samantha Vogt Headshot