Training Years: 2017-2018
Training Site: UNC Project-Malawi
Mentors: Mina Hosseinipour, MD, MPH
Title: An evaluation of bone mineral content in Malawian infants as a measure of fetal bone effects of maternal tenofovir use in utero and during breastfeeding at 12 months postpartum
Project Objectives: The goal of this study is to evaluate fetal bone effects of maternal tenofovir (TDF) use in utero and during breastfeeding on HIV exposed but uninfected infants (HEUC). The specific aim is:
Aim 1: To compare whole-body bone mineral content (BMC) of HEUC exposed to TDF vs not exposed to TDF (mothers taking ART regimens without TDF) vs HIV unexposed infants (mothers are HIV negative) by measuring the BMC using a dual-energy absorptiometry (DXA) scan at 12 months postpartum.
NIH Support: Fogarty fellows postdoctoral training award