Completed Studies

HIV Prevention Trials Network (HPTN) 083 (2016-2021)

Safe and effective options for pre-exposure prophylactics (PrEP) are needed to prevent HIV. HPTN 083 was a double-blinded randomized controlled trial that evaluated the safety and effectiveness of long-acting injectable cabotegravir (CAB LA) compared to daily oral tablets of TDF/FTC among cis-gender men who have sex with men and transgender women. Vietnam was one of 43 sites globally. CAB LA was superior to daily oral TDF/FTC for PrEP in preventing HIV infections among participants enrolled in the study.

Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women [HPTN 083]. Landovitz R, Donnell D, Clement M, Hanscom B, Cottle L, Coelho L,…; HPTN 083 Study Team. NEJM. 2021, 385: 595-608

Quality of Tuberculosis Services Assessments (QTSA) (2023)

Tuberculosis (TB) is the tenth leading cause of death globally; improving the quality of care in TB services can contribute to better TB patient health outcomes. The QTSA is a facility-based assessment conducted in multiple countries, including Vietnam, to evaluate the quality of TB services in randomly selected health facilities. The findings can assist policy makers, program managers, and service providers to strengthen the quality of TB services.

Genomic epidemiology of Treponema pallidum strains infecting women and men in low- and middle-income countries to inform syphilis vaccine development (2021-2022)

The purpose of this research study is to understand the differences in syphilis strains worldwide that will be important to future vaccine development. We collected biological specimens from syphilis patients in multiple sites across Asia, Africa, and South America to evaluate the causal pathogen (Treponema pallidum) and generate new genomic sequences. These sequences will be used to better understand global patterns of T. pallidum genomic diversity as well as inform future vaccine development.

Reducing Hazardous Alcohol Use and HIV Viral Load: An RCT in ART Clinics in Vietnam (REDART) (2016 – 2018)

People with HIV (PWH) who have unhealthy alcohol use tend to have worse HIV-related outcomes. In this randomized controlled trial, PWH with unhealthy alcohol use were randomized to standard of care, a brief alcohol intervention, or a combined intervention of motivational enhancement therapy and cognitive behavioral therapy. The brief alcohol intervention, but not the combined intervention, improved viral suppression. Both interventions increased the number of days abstinent from alcohol.

Effect of 2 Integrated Interventions on Alcohol Abstinence and Viral Suppression Among Vietnamese Adults With Hazardous Alcohol Use and HIV: A Randomized Clinical Trial. Go VF, Hutton HE, Ha TV, Chander G, Latkin CA, Mai NVT, Quynh BX, Nguyen V, Sripaipan T, Lancaster KE, Blackburn N, Hershow RB, Dowdy DW, Frangakis C. JAMA Netw Open. 2020 Sep 1;3(9):e2017115.

The Cost-Effectiveness of Adapting and Implementing a Brief Intervention to Target Frequent Alcohol Use Among Persons with HIV in Vietnam. Blackburn NA, Go VF, Bui Q, Hutton H, Tampi RP, Sripaipan T, Ha TV, Latkin CA, Golden S, Golin C, Chander G, Frangakis C, Gottfredson N, Dowdy DW. AIDS Behav. 2021 Jul;25(7):2108-2119.

HIV Prevention Trials Network (HPTN) 074 (2015 – 2018)

HPTN 074 was conducted with people who inject drugs (PWID) in Vietnam, Indonesia, and Ukraine. PWID with HIV received either standard of care or an intervention including systems navigation and psychosocial counseling (SNaP). SNaP was designed to help PWID access and sustain antiretroviral therapy (ART). This short intervention improved ART use, viral suppression, and use of medications for opioid use disorder; it also reduced mortality.

A scalable, integrated intervention to engage people who inject drugs in HIV care and medication-assisted treatment (HPTN 074): a randomised, controlled phase 3 feasibility and efficacy study. Miller WC, Hoffman IF, Hanscom BS, Ha TV, Dumchev K, Djoerban Z, Rose SM, Latkin CA, Metzger DS, Lancaster KE, Go VF, Dvoriak S, Mollan KR, Reifeis SA, Piwowar-Manning EM, Richardson P, Hudgens MG, Hamilton EL, Sugarman J, Eshleman SH, Susami H, Chu VA, Djauzi S, Kiriazova T, Bui DD, Strathdee SA, Burns DN. Lancet. 2018 Sep 1;392(10149):747-759.

Prevention for Positives: An RCT among Vietnamese PWID (2009 – 2015)

People who inject drugs (PWID) with HIV often face both HIV and substance use-related stigma in the community. This four-armed randomized controlled trial compares a multileveled individual and community stigma-reduction intervention to an individual counseling intervention alone, the community- based intervention alone and the standard of care. We enrolled 455 PWID with HIV from 32 communes in Thai Nguyen. The multilevel intervention reduced mortality and increased ART uptake.

The Effect of a Multi-Level Intervention on the Initiation of Antiretroviral Therapy (ART) among HIV-Infected Men Who Inject Drugs and Were Diagnosed Late in Thai Nguyen, Vietnam. Zelaya CE, Le Minh N, Lau B, Latkin CA, Viet Ha T, Minh Quan V, Mo TT, Sripaipan T, Davis WW, Celentano DD, Frangakis C, Go VF. PLoS One. 2016 Aug 31;11(8):e0161718.

Increased Survival Among HIV-Infected PWID Receiving a Multi-Level HIV Risk and Stigma Reduction Intervention: Results From a Randomized Controlled Trial. Go VF, Frangakis C, Le Minh N, Ha TV, Latkin CA, Sripaipan T, Zelaya CE, Davis WW, Celentano DD, Quan VM. J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):166-174.

HIV Negatives

Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: a randomized controlled trial. Go VF, Frangakis C, Le Minh N, Latkin CA, Ha TV, Mo TT, Sripaipan T, Davis W, Zelaya C, Vu PT, Chen Y, Celentano DD, Quan VM. Soc Sci Med. 2013 Nov;96:154-64.