UCHCC was created in 1999 to provide a resource for addressing pressing clinical care issues facing patients with HIV-infection. UCHCC has grown to include over 5,000 HIV-infected patients, with a rich specimen repository, patient reported outcomes and a comprehensive demographic, clinical, behavioral and socio-structural survey. UCHCC has been linked with local, state and national data sources. UCHCC data are available to HIV care providers through an individual Patient Summary Report and in aggregate to support the management of HIV care provision and clinical trial enrollment at UNC. The UCHCC has supported a variety of investigator initiated research efforts, spanning basic science, translational research, clinical care, epidemiology and public health, and collaborates with leading national and international HIV multi-cohort efforts including CNICS and NA-ACCORD.