Tag: Edward Browne

Dr. Edward Browne, associate professor of medicine leading the Browne Lab within the HIV CURE Center, focuses on developing methods for studying and eliminating the latent HIV reservoir from infected patients. Latently infected cells are resistant to current HIV therapies and can persist in infected patients for decades. He recently...

Edward P. Browne, PhD, conducted a review that outlines current model systems of HIV latency and their analysis with single-cell omics technologies. Several recent papers have applied cutting-edge single-cell omics methods to model systems of HIV latency. Single-cell technologies provide sensitive detection of cellular subpopulations that contribute to proviral reactivation...

Biomarkers or medical data verified by a medical provider are generally considered to be more reliable than self-reported data, but researchers often face challenges when collecting medical record verification or biomarkers from young adults (YA) in research. Edward P. Browne, PhD, and Audrey Pettifor, PhD, analyzed data from a randomized controlled...

The latent HIV reservoir is a major barrier to HIV cure. Despite advancements in keeping viral loads below detectable limits, HIV-1 still exists within a latent reservoir in vivo and viral replication returns when anti-retroviral therapy (ART) is interrupted. Nancie M. Archin, PhD, and Edward P. Browne, PhD, sought to...

Human Immunodeficiency virus (HIV) infection is regulated by various host cell factors that combine to influence viral transcription and latency. To understand the complex relationship between the host cell and HIV-1 latency, Edward Browne, PhD, Nancie M. Archin, PhD, and David Margolis, MD, performed a lentiviral CRISPR screen that targeted a...

Investigators with the Institute for Global Health and Infectious Diseases (IGHID) participated in the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco, California, March 9-12. Following are some highlights.   In a CROI preview, Joe Eron, MD, was interviewed for the “Going Anti-Viral” IAS-USA podcast, discussing the...

HIV/AIDS has been around for approximately 40 years, but many researchers say the end is in sight. The question is, will it be in our lifetime or just around the corner? This is a spotlight on the HIV CURE Center, comprising approximately 55 researchers and students, featuring David Margolis, MD, the...