About

Lindsey James, PhD, is a researcher with the HIV Cure Center, an assistant professor at the UNC Eshelman School of Pharmacy, and a member of UNC Lineberger Comprehensive Cancer Center, focused on medicinal chemistry and epigenetics to accelerate drug treatment.

Dr. James’ interest in chemistry was first sparked by her high school AP Chemistry teacher. She pursued a chemistry major at Colgate University and became drawn to research while getting her bachelor’s degree.

She has a specific interest in epigenetic regulators, toward the study of HIV latency, as strategies that promote viral reactivation by disrupting repressive epigenetic processes represent a promising step toward a cure for HIV.

In the news

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  Lindsey James Wins 2025 Hettleman Prize

  Lindsey James, PhD, is one of five early career faculty to win a 2025 Hettleman Prize, which recognizes groundbreaking, innovative research and future career promise. James is a member of the HIV Cure Center through the Institute for Global Health and Infectious Diseases, assistant professor with the UNC Eshelman School of Pharmacy, (James Lab), and … Read more

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  BET Degraders Reveal BRD4 Disruption of 7SK and P-TEFb is Critical for Effective Reactivation of Latent HIV in CD4+ T-cells

  HIV cure strategies that aim to induce viral reactivation for immune clearance leverage latency reversal agents to modulate host pathways, which directly or indirectly facilitate viral reactivation. Inhibition of BET (bromo and extra-terminal domain) family member BRD4 reverses HIV latency, but enthusiasm for the use of BET inhibitors in HIV cure studies is tempered by … Read more