About

The Jiang lab at the UNC HIV Cure Center and the Department of Biochemistry & Biophysics aims to understand the molecular mechanisms behind stable HIV reservoirs in resident immune cells, including T cells and non-T cells, in people with HIV (PWH) on suppressive antiretroviral therapy (ART). We focus on both epigenetic and non-epigenetic regulation of HIV transcription and latency. Various in vitro, ex vivo, and in vivo models of HIV infection and latency are being pursued, including HIV-infected humanized mouse models, SIV-infected rhesus macaques, and PWH on ART. Traditional biochemistry, molecular biology, and virology approaches are employed in these studies, while modern omics analyses are actively explored to address the extremely challenging questions surrounding HIV latency. Our goal is to translate our understanding of HIV persistence into therapeutic interventions for a potential cure.

Awards and honors

• American Society of Biochemistry and Molecular Biology (ASBMB)
• American Society for Microbiology (ASM)
• International Society for NeuroVirology (ISNV)

Education