Guochun Jiang, PhD
Assistant Professor of Biochemistry and Biophysics, Jiang Lab
Areas of Interest
HIV latency, Epigenetic regulation of HIV, HIV tissue reservoirs, HIV cure strategies
About
The Jiang lab at the UNC HIV Cure Center and the Department of Biochemistry & Biophysics aims to understand the molecular mechanisms behind stable HIV reservoirs in resident immune cells, including T cells and non-T cells, in people with HIV (PWH) on suppressive antiretroviral therapy (ART). We focus on both epigenetic and non-epigenetic regulation of HIV transcription and latency. Various in vitro, ex vivo, and in vivo models of HIV infection and latency are being pursued, including HIV-infected humanized mouse models, SIV-infected rhesus macaques, and PWH on ART. Traditional biochemistry, molecular biology, and virology approaches are employed in these studies, while modern omics analyses are actively explored to address the extremely challenging questions surrounding HIV latency. Our goal is to translate our understanding of HIV persistence into therapeutic interventions for a potential cure.
Awards and honors
- 2024-CFAR I-SURC In-Person Meeting Travel Award at CROI 2024, Denver, USA
- 2023-Collaborative Development Program Award, Behavior of HIV in Viral Environments Center, the Seatle’s Children’s Hospital and NIAID
- 2022-Chromatin Control of Viral Infection, Travel Award, NIH campus at Bethesda, USA
- EB2022 ASBMB Early Career Faculty Travel Award, Philadelphia, USA
- 2020-2021 Center for AIDS Research Developmental Award
- 2019 CFAR Early Stage Investigator (ESL)
- 2019-Presence Elected to the Editorial Board in the Frontiers in Microbiology journal
- 2018-2019 UC Davis CRCF Pilot & Feasibility Program Award
- 2016-2017 UC Davis Academic Senate Travel Award
- 2015-2016 UC Davis Academic Senate Travel Award
- 2010 NIH Keystone Scholarship, USA
- 2007-2010 Ruth L. Kirschstein National Research Service Award (NRSA), Vanderbilt University
- 2007 CROI, Young Investigator Award, Los Angeles, USAM
Memberships
- American Society of Biochemistry and Molecular Biology (ASBMB)
- American Society for Microbiology (ASM)
- International Society for NeuroVirology (ISNV)
In the news
HIV/AIDS has been around for approximately 40 years, but many researchers say the end is in sight. The question is, will it be in our lifetime or just around the corner? This is a spotlight on the HIV CURE Center, comprising approximately 55 researchers and students, featuring David Margolis, MD, the director, Nancie Archin, PhD, a … Read more HIV virus eradication is a complex health challenge due to its long-lived persistence and how it hides in latently infected cells that escape the body’s immune system. Effective HIV treatments have decreased the likelihood of someone developing AIDS, while helping individuals live long and healthy lives without transmission to sexual partners. But for individuals with long-standing … Read more Angela Wahl, PhD, a member of the Institute for Global Health & Infectious Diseases (IGHID), the International Center for the Advancement for Translational Science, and assistant professor in the division of infectious diseases has received a $3.2 million R01 award to study the role of microglia in HIV latency and persistence in the brain. Over … Read more
IAMIGHID: Spotlighting the HIV Cure Team
Some of the Many Faces of HIV Research: Treatment, Prevention and Pursuing a Cure
Wahl Receives $3.2 Million to Study the Neurological Consequences of HIV Infection
Education
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Undergraduate
Anhui University
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Medical School
Academy of Military Medical Sciences
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Fellowship
University of North Carolina at Chapel Hill
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Fellowship
Vanderbilt University