Dr. Gaynes’s research focuses on the development and implementation of evidence-based management strategies to treat mental illness, with an emphasis on large-scale clinical trials and health services research. He is an expert in measurement-based-care depression management using pharmacologic and cognitive behavioral interventions, like the Friendship Bench (FB). His efforts combine clinical trial expertise and the use of evidence-based treatment algorithms for managing depressive illness in non-psychiatric medical settings. He is nationally and internationally recognized for my clinical and research efforts on integrating mental health and primary care and translating evidence-based psychiatric care into real-world psychiatric and primary care practices, with a special focus on disseminating evidence-based psychiatric interventions in HIV settings in low- and middle-income countries. He has led or co-led pilots, demonstration projects, full-scale effectiveness trials, and implementation trials in this area in the US, Vietnam, Cameroon, and Malawi.