Current studies
ACTG A5354
Effect of Antiretroviral Treatment Initiated during Acute HIV-1 Infection on measures of HIV-1 Persistence and on HIV-1- Specific Immune Responses
Prof. Mina Hosseinipour
ACTG 5362
Phase IIc Trial of Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis
Dr. Cecilia Kanyama
ACTG 5381
Observational Cohort to Assess Therapeutic Efficacy and Emergence of HIV Drug Resistance Following Initiation of Tenofovir-Lamivudine-Dolutegravir (TLD) for First- or Second-Line ART or with Rifampicin-Containing TB Treatment
Dr. Cecilia Kanyama
CIPHER-EID
Feasibility pilot to characterize a differentiated service delivery model for hiv early infant diagnosis in high-risk mother-infant pairs
Dr. Maganizo Chagomerana
CoVPN 3008
A randomized efficacy study of a COVID-19 mRNA 2-dose Vaccine in African regions with SARS-CoV-2 variants of concern.
Prof. Mina Hosseinipour, Dr. Friday Saidi
ENHANCE-CBR
Enhancing post-acute mental health outcomes for patients with psychosis in Malawi through nurse-delivered community-based rehabilitation:
Dr. Sarah Rustein
EMPIRICAL
A multicenter, open-label randomized controlled clinical trial for treatment against cytomegalovirus and tuberculosis in HIV infected infants with severe pneumonia
Dr. Tisungane Mvalo
HPTN 084 open label extension
A Phase 3 Double Blind Safety and Efficacy Study of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women
Prof. Mina Hosseinipour
IMPAACT P1115
Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum
Dr. Lameck Chinula
IMPAACT 2016
Evaluation of a group based intervention to improve mental health and ART adherence among youth living with HIV in low resource setting
Dr. Lameck Chinula
IMPAACT 2026
Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum
Dr. Lameck Chinula
IMPAACT 2028
It is a multisite observational study of long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV
Dr. Lameck Chinula
AMP ATI
(HVTN 805/HPTN 093)
An Antiretroviral analytical treatment interruption study (ATI)
Prof. Mina Hosseinipour
SAVI
Global sequence and surface antigenic diversity of Treponema pallidum outer membrane proteins
Prof. Irving Hoffman, Dr. Mitch Matoga
AMC 100
A Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Positive Individuals With Kaposi Sarcoma (KS) in Sub-Saharan Africa (SSA)
Dr. Lusayo Simwinga
AMC 099
A Randomized, Placebo-Controlled Trial of HPV Vaccination to Reduce Cervical High-Grade Squamous Intraepithelial Lesions among HIV-Infected Women Participating in an HPV Test-and-Treat Program (COVENANT)
Dr. Lameck Chinula
LCCC 1905
A novel cervical cancer screen-and-treat demonstration project with HPV self-testing and thermocoagulation for women in Lilongwe, Malawi
LCCC 1940
Isothermal Acid Amplification System Device
LCCC 1950
Rituxmab for multicentric Castleman disease in Malawi, a single-arm phase ii safety/ efficacy trial
UNCPM 21410
Option B+ ART Safety and Durability during first and subsequent pregnancies
Prof. Mina Hosseinipour
Host Directed Immune Modulatory therapy in cryptococcal meningitis (HIT-CRYPTO)
Dr. Cecilia Kanyama
A prospective cohort evaluating the pregnancy rates and pharmacokinetic interactions among HIV-infected Malawians on Efavires or Dolutegravir initiating the Levonorgestrel Implant or the Depot Medroxyprogestetrone Acetate Injectable
Dr. Jennifer Tang
Uptake of voluntary medical male circumcision among men attending a sexually transmitted infections clinic Lilongwe, Malawi
Dr. Mitch Matoga
UNCPM 22201 HIV Engagement and Adolescent Depression Support
Prof. Bradley Gaynes
LCCC 1229
Developing a Prospective Lymphoma Clinical Cohort in Malawi
Prof. Yuri Fedoriw
UNCPM 21918 Perspectives on the provision of abortion and post-abortion care in Malawi: A Qualitative Study
Dr. Friday Saidi
Secondary Analysis of STI Clinic Data at Bwaila Hospital, Malawi
Dr. Mitch Matoga
A5384
A Phase II Randomized, Open-Label Trial of a Six-Month Regimen of High-dose Rifampicin, High-dose Isoniazid, Linezolid, and Pyrazinamide versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents with Tuberculous Meningitis: Improved Management with Antimicrobial AGents Isoniazid rifampiciN LinEzolid for TBM (IMAGINE-TBM).
Dr. Cecelia Kanyama
HVTN 405/HPTN 1901
Characterizing SARS-CoV-2-specific immunity in convalescent individuals
Dr. Melda Phiri
AMC-104
Feasibility study of ocular surface squamous neoplasia (OSSN) surgical excision in people living with HIV in sub-Saharan Africa (SSA)
Dr. Amos Nyaka
Understanding Engagement to HIV Prevention and Sexual and Reproductive Health Services among Women after Participating in an HIV Vaccine Trial
Dr. Mitch Matoga
IGHID 11904: Global sequence and surface antigenic diversity of Treponema pallidum outer membrane proteins
Dr. Mitch Matoga
IGHID 12057 Barriers and Facilitators of Syphilis Vaccine Trial Participation
Dr. Mitch Matoga
IGHID 12140 Genomic epidemiology of Treponema pallidum strains infecting women and men in low- and middle-income countries to inform syphilis vaccine development
Dr. Mitch Matoga
IGHID 12235 PRomoting Equity for Pregnant Adolescents in HIV REsearch (PREPARE) in Malawi, Botswana, South Africa, and the USA
Dr. Agatha Bula
LCCC 1905 – A Novel Cervical Cancer Screen-and-Treat Demonstration Project with HPV Self-testing and Thermocoagulation for women in Lilongwe, Malawi
Dr. Lameck Chinula
LCCC 2127
A prospective observational clinical cohort study to assess the safety and efficacy of standard of care risk-adjusted pediatric Burkitt lymphoma treatment incorporating high-dose Methotrexate in Malawi.
Dr. Kate Westmoreland
LCCC 2122 – Women’s perceptions and attitudes towards mobile phone text messaging as a model of communication to receive HPV results and remind women to report for cervical cancer treatment in Lilongwe, Malawi.
John Chapola
LCCC 2147 – Implementing a Breast Cancer Screening/Early Detection Intervention for Cervical Cancer Screening Providers in Malawi
Dr. Tamiwe Tomoka
LCCC 2151: Validation and administration of a new tablet-based voice-enabled application to measure patient-reported outcomes (PROs) among low-literacy pediatric and adolescent hematology-oncology patients in Malawi
Dr. Kate Westmoreland
UNCPM-22301-Using Implementation Science to Accelerate a Path to Scale for Injectable PrEP in Malawi. An implementation Phase.
Dr. Agatha Bula
UNCPM 22212
Enhanced detection of treatable infections in Malawian children under five years with complicated severe acute malnutrition
Dr. Tisungane Mvalo and Dr. Bryan Vonasek
UNCPM 22210
An international repeated cross-sectional observational study of blood donation in Sub-Saharan Africa
Dr. Maganizo Chagomerana
UNCPM 22209
Enhancing post-acute mental health outcomes for patients with psychosis in Malawi through nurse-delivered community-based rehabilitation: The ENHANCE Pilot
Dr. Brian Pence
UNCPM 22206: Evaluating the Risk and Impact of Aspiration in Breastfed Infants with Severe Pneumonia in Malawi\
Dr. Nadia Hoeskra
UNCPM 22201 – HIV Engagement and Adolescent Depression Support
Prof. Bradley Gaynes
UNCPM 22118 – Treatment outcomes following thermal ablation treatment among HIV+ and HIV- women in Malawi
Dr. Chemtai Mungo
UNCPM 22115: Integrating Enhanced HIV Pre-exposure Prophylaxis into a Sexually Trasmitted Infection Clinic in Lilongwe
Dr. Sarah Rustein
UNCPM 22113: Impact of Parasistic Infections on Intestinal Epithelial Barrier and Immune Activation among Persons Living with HIV in Lilongwe-Malawi
Dr. Melissa Reimer-McAtee
UNCPM 22109: Evaluation of Rituximab on Malaria-specific Immunological Profile and Subsequent Risk of Malaria among DLBCL Patients in a Malaria Endemic Region
Dr. Matthews Painschab
UNCPM 22106: Erythrocyte Alloimmunization Among Transfused Children with Sickle Cell Anemia in Malaw
Dr. Russell Ware
UNCPM 22102 – Improving case detection of tuberculosis in children with severe acute malnutrition in Malawi
Bryan Vonasek