HIV-Associated Malignancies

High Cancer Burden Among ART Users in Malawi

December 2018- In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users. We link cases from the population-based cancer registry with EMRs supporting ART delivery in Malawi’s two largest HIV cohorts, Lighthouse Trust and Queen Elizabeth Central Hospital to identify cancer burden.

HIV-Associated Multicentric Castleman Disease In Malawi

November 2018-  Despite high burden of Kaposi sarcoma and HIV, multicentric Castleman disease is rarely reported in SSA. To supplement previous reports on MCD cases in Malawi, we describe a larger cohort of MCD patients with longer follow-up.

Frequent HIV and Young Age Among Individuals With Diverse Cancers

June 2018- We report the epidemiology of patients with cancer recorded by a hospital-based cancer registry at Kamuzu Central Hospital, the sole provider of comprehensive oncology services for half the country and location of a high-volume pathology laboratory.

CD4 Count and HIV RNA Trends for HIV-Associated Lymphoproliferative Disorders in Malawi

October 2017 – Given scarce data from sub-Saharan Africa, we describe CD4 count and HIV RNA trends over time among patients with HIV-positive lymphoproliferative disorders in Malawi.

Kaposi’s sarcoma in Malawi: a continued problem for HIV-positive and HIV-negative individuals

January 2017- Kaposi’s sarcoma (KS) is the leading cancer in much of sub-Saharan Africa. HIV has resulted in a dramatic increase in KS throughout the region, due to high overlapping prevalence of HIV and the etiologic agent of KS, Kaposi’s sarcoma-associated herpesvirus. We sought to describe contemporary burden and characteristics of KS in the HIV+ and … Read more

HIV-associated malignancies in sub-Saharan Africa: an overview

January, 2017 – This review highlights recent developments for HIV-associated malignancies in low and middle income countries and suggests that sustained investment within these settings can help catalyze a cancer care and research agenda that benefit patients worldwide.

Excellent Clinical Outcomes for Adults with HIV-Associated Kaposi Sarcoma

May 2015 – HIV-associated Kaposi Sarcoma is the most common cancer in Malawi. This retrospective cohort study found that providing standard-of-care chemotherapy regimens from the developed world was both effective and feasible. 

Multiple Subtypes of Kaposi’s Sarcoma

September 2014 – Using viral transcription profiling, this study demonstrates the existence of multiple subtypes of Kaposi Sarcoma lesions for the first time in HIV- and Kaposi Sarcoma-treatment-naive patients.  

Multicentric Castleman’s Disease in Malawi

September 2014 – A case study highlighting the need to increase familiarity with multicentric Castleman’s disease among clinicians and pathologists in Kaposi sarcoma-associated herpesvirus endemic regions, and to develop high-quality diagnostic pathology services throughout sub-Saharan Africa.