Training Years: 2016-2017
Training Site: Institute for Clinical Effectiveness and Health Policy IECS)
Mentor: Adolfo Rubinstein, MD, MSc, PhD; Jiang He MD, PhD
Title: Do available cardiovascular risk prediction models from developed countries perform well in the Southern Cone of Latin America?
Hypothesis: We hypothesize that most of the current scores overestimate the global cardiovascular risk in the southern cone population.
Aim 1: To assess the goodness-of-fit and discrimination of different risk score equations (Framingham Heart Study, PROCAM, QRISK, SCORE and INTERHEART) on a population-based prospective cohort of the Southern Cone of Latin America.
Hypothesis: We hypothesize that CRP is highly associated with cardiovascular risk events in the Southern Cone of Latin America.
Aim 2: To assess the relationship between serum levels of C-reactive protein (CRP) and incidence of cardiovascular events in a subset of subjects with high cardiovascular disease (CVD) risk from a population based prospective cohort of the Southern Cone of Latin America.
Hypothesis: We hypothesize that the inclusion of CRP into multivariable risk prediction models will improve both prediction and calibration of CVD events in a very high cardiovascular risk population.
Aim 3: To assess the improvement in the prediction models performance (net reclassification improvement and integrative discrimination index) by including CRP into the equations among people with high cardiovascular risk.
NIH Support: Fogarty fellowship postdoctoral training award