Years: 2020 – 2021
Training Site: UNC Project-Malawi
Mentors: Jennifer Tang, MD, MSCR; Jennifer Smith & Lameck Chinula, MMED, FCOG
Title: “Evaluation and comparison of high-risk HPV type distribution in cervical lesions of HIV positive and HIV negative women in Malawi”
Aim 1: Describe type-specific HPV prevalence among a spectrum of histologically-confirmed cervical samples (normal, cervical Intraepithelial Neoplasia (CIN) 1, CIN2, CIN3, and invasive cervical cancer) in HIV-positive and HIV-negative women in Lilongwe, Malawi.
Aim 2: Compare the overall and type-specific prevalence of HPV between HIV-positive and HIV-negative women, stratified by histological disease stage.
Aim 3: Compare the prevalence of type-specific HPV infection and associated cervical disease, stratified by CD4 count (CD4>500, 350-500, and <350 cells/cubic millimeter) in HIV-positive women.
NIH Support: FIC-AIDS/NCI