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Training Years: 2015-2016

Training Site: Infectious Diseases Institute, Makerere University

Country: Uganda

Mentors: Yuka Manabe, MD, MSc; Barbara Castelnuovo, MBChB, MRCP, PhD

Title: Correlation of pharmacokinetic parameters of anti-TB drugs with TB treatment outcomes in TB-HIV co-infected patients: A systematic review in the context of a clinical trial. 

Project Objectives:  

Aim 1: To investigate the association between the pharmacokinetic parameters of isoniazid and rifampicin and time to sputum smear and/or culture conversion in TB/HIV co- infected individuals.

Aim 2: To determine the predictors (demographic and pharmacokinetic) of TB treatment outcome at 12 months in TB/HIV co-infected individuals.

NIH Support:  Fogarty fellowship postdoctoral training award

Career Development Award: European and Developing Countries Clinical Trials Partnership TMA2016CDF-1580 (2018-2020) Safety and efficacy of high-dose rifampicin in TB-HIV co-infected patients on efavirenz-based antiretroviral therapy; Infectious Diseases Institute Limited (IDI), Kampala, Uganda

Christine Sekaggya-Wiltshire Headshot