Training Years: 2017-2018
Training Site: UNC Project-Malawi
Country: Malawi
Mentors: Jennifer Tang; Amanda Corbett
Title: Evaluation of the effect of Efavirenz on Levonorgestrel pharmacokinetics over 24 weeks among HIV-infected women using the Levonorgestrel contraceptive implant
Project Objectives:
Hypothesis: We hypothesize that the 24-week mean LNG concentration among EFV 400 mg users will be at least 33% higher than the 24-mean LNG concentration previously found among EFV 600 mg users who were using the LNG implant because of decreased EFV exposure and pharmacokinetic parameters.
Aim 1: To evaluate the effect of Efavirenz (EFV) on Levonorgestrel (LNG) concentrations among 22 HIV-infected women who are using the LNG contraceptive implant and taking EFV 400 mg daily over 24 weeks of drug co-administration.
NIH Support: Fogarty scholars doctoral training award
