Edward P. Browne, PhD, conducted a review that outlines current model systems of HIV latency and their analysis with single-cell omics technologies. Several recent papers have applied cutting-edge single-cell omics methods to model systems of HIV latency.
Single-cell technologies provide sensitive detection of cellular subpopulations that contribute to proviral reactivation and latency, making them advantageous to apply to widely used cell lines and primary cell models of HIV latency. These studies have increased our understanding of HIV latency model systems and generated novel hypotheses that can be tested in clinical samples from people with HIV.