CROI 2009

This week infectious disease specialists, microbiologists, immunologists, biostatisticians and other scientists are gathered in Montréal for the 16th Conference on Retroviruses and Opportunistic Infections.

UNC-Chapel Hill has a strong presence at the conference, with a total of 27 abstracts accepted.  The complete list after the jump.

Title: Clinical, Immunological, and Virological Outcomes of Second-line Treatment, Malawi

Authors and Affiliations: Mina Hosseinipour*1,2, J Kumwenda3, R Weigel4, L Brown2, D Mzinganjira1, B Mhango3, S Phiri4, and J Van Oosterhout3,5

1Univ of North Carolina Project, Lilongwe, Malawi; 2Univ of North Carolina at Chapel Hill, US; 3Univ of Malawi Coll of Med, Blantyre; 4Lighthouse Trust, Lilongwe, Malawi; and 5Malawi-Liverpool Wellcome Trust, Coll of Med, Blantyre, Malawi

Title: Single-dose Tenofovir Disoproxil Fumarate with and without Emtricitabine in HIV-1-infected Pregnant Women and Their Infants: Pharmacokinetics and Safety

Authors and Affiliations: Patricia Flynn*1, M Mirochnick2, D Shapiro3, A Bardeguez4, S Huang3, S Fiscus5, J Rooney6, H Watts7, L Mofenson7, P Jean-Philippe8, and PACTG/IMPAACT 394 Study Team

1St Jude Children`s Res Hosp, Memphis, TN, US; 2Boston Med Ctr, Boston Children`s Hosp, MA, US; 3Statistical and Data Analysis Ctr, Harvard Sch of Publ Hlth, Boston, MA, US; 4Univ of Med and Dentistry of New Jersey, Newark, US; 5Univ of North Carolina at Chapel Hill, Sch of Med, US; 6Gilead Sci, Foster City, CA, US; 7Natl Inst of Child Hlth and Human Devt, NIH, Rockville, MD, US; and 8Henry M Jackson Fndn, Div of AIDS, NIAID, NIH, Bethesda, MD, US

Title: Multiple Class I Histone Deacetylases Maintain HIV-1 Transcriptional Repression during Proviral Latency

Authors and Affiliations: Kara Keedy*1, N Archin1, A Gates2, A Espeseth2, D Hazuda2, and D Margolis1

1Univ of North Carolina at Chapel Hill, US and 2Merck Res Labs, West Point, PA, US

Title: Comparison of HIV-1 in Blood and Seminal Plasma Reveals Distinct States of Compartmentalization

Authors and Affiliations: Li-Hua Ping*1, J Anderson1, L Arney1, C Jabara1, I Hoffman1, P Kazembe2, M Maida2, S Fiscus1, M Cohen1, and R Swanstrom1

1Univ of North Carolina at Chapel Hill, US and 2Lilongwe Central Hosp, Malawi

Title: 96-Week Results from BENCHMRK 1 and 2, Phase III Studies of Raltegravir in Patients Failing ART with Triple-class-resistant HIV

Authors and Affiliations: Roy Steigbigel*1, D Cooper2, J Eron3, J Gatell4, P Kumar5, J Rockstroh6, H Wan7, P Sklar7, H Teppler7, B-Y Nguyen7, and BENCHMRK-1 and 2 Study Groups

1State Univ of New York at Stony Brook, US; 2Univ of New South Wales, Sydney, Australia; 3Univ of North Carolina at Chapel Hill, US; 4Univ of Barcelona, Spain; 5Georgetown Univ Med Ctr, Washington, DC, US; 6Univ of Bonn, Germany; and 7Merck Res Labs, West Point, PA, US

Title: Serum and Cerebrospinal Fluid Concentration Monitoring for High-dose Fluconazole in HIV-associated Cryptococcal Meningitis-infected Patients

Authors and Affiliations: Weerawat Manosuthi*1, P Chetchotisakd2, S Sungkanuparph3, T Anekthananon4, K Supparatpinyo5, T Nolen6, D Wallace7, P Pappas8, S Filler9, D Andes10, and BAMSG 3-01 Study Team

1Bamrasnaradura Infectious Disease Inst, Nonthaburi, Thailand; 2Faculty of Med, Khon Kaen Univ, Thailand; 3Faculty of Med, Ramathibodi Hosp, Mahidol Univ, Bangkok, Thailand; 4Faculty of Med, Siriraj Hosp, Mahidol Univ, Bangkok, Thailand; 5Faculty of Med, Chiang Mai Univ, Thailand; 6Rho Federal Systems Div Inc, Chapel Hill, NC, US; 7Res Triangle Inst, Durham, NC, US; 8Univ of Alabama at Birmingham Med Ctr, US; 9Los Angeles Biomed Res Inst at Harbor-Univ of California, Los Angeles Med Ctr, Torrance, US; and 10Univ of Wisconsin-Madison, US

Title: Prevalence of Transmitted HIV-1 Drug Resistance among Young Men of Color Who Have Sex with Men: A Multicenter Cohort Analysis

Authors and Affiliations: Lisa Hightow-Weidman*1, G Phillips II2, J Smith1, K Jones2, M Magnus2, A Outlaw3, T Giordano4, E Enriquez-Bruce5, M Tinsley6, and J Hidalgo2

1Univ of North Carolina at Chapel Hill, US; 2George Washington Univ Sch of Publ Hlth and Hlth Svcs, Washington, DC, US; 3Horizons Project, Wayne State Univ, Detroit, MI, US; 4Baylor Coll of Med and Thomas St Hlth Ctr, Houston, TX, US; 5Bronx AIDS Svcs Inc and Children`s Hosp at Montefiore, NY, US; and 6Hlth Resources and Svcs Admin, HIV/AIDS Bureau, Special Projects of Natl Significance, Rockville, MD, US

Title: Effect of Maternal HAART on Postnatal HIV-1 Transmission after Cessation of Extended Infant Antiretroviral Prophylaxis

Authors and Affiliations: T Taha1, J Kumwenda2, S Cole3, D Hoover4, G Kafulafula2, Q Li1, M Thigpen5, M Glenn Fowler6, N Kumwenda1, and Lynne Mofenson*7

1Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US; 2Univ of Malawi Coll of Med, Blantyre; 3Univ of North Carolina at Chapel Hill, US; 4Rutgers Univ, Piscataway, NJ, US; 5CDC, Atlanta, GA, US; 6Johns Hopkins Med Insts, Baltimore, MD, US; and 7Natl Inst of Child Hlth and Human Devt, NIH, Bethesda, MD, US

Title: No Evidence for Decay in the Latent Reservoir in HIV-infected Patients Receiving Intensive Enfuvirtide-containing ART

Authors and Affiliations: Rajesh Gandhi*1, R Bosch2, E Aga2, M Albrecht3, E Adams4, L Demeter5, B Bastow6, R Siliciano7, J Siliciano7, J Eron8, and ACTG A5173

1Massachusetts Gen Hosp, Boston, US; 2Harvard Sch of Publ Hlth, Boston, MA, US; 3Beth Israel Deaconess Hosp, Boston, MA, US; 4NIH, Bethesda, MD, US; 5Univ of Rochester, NY, US; 6Social & Sci Systems Inc, Silver Spring, MD, US; 7Johns Hopkins Hosp, Baltimore, MD, US; and 8Univ of North Carolina at Chapel Hill, US

Title: Age-specific CD4 Percentage and Weight/Growth Curves to Predict Survival and Virological Response to HAART

Authors and Affiliations: Marcel Yotebieng*1, H Moultrie2, A Vanrie1, and T Meyers2

1Univ of North Carolina at Chapel Hill, US and 2Harriet Shezi Children`s Clinic, Chris Hani Baragwanath Hosp, Univ of the Witwatersrand, Johannesburg, South Africa

Title: Characteristics Associated with Retention for Hard-to-Reach Young Men of Color Who Have Sex with Men

Authors and Affiliations: Manya Magnus*1, K Jones1, G Phillips II1, D Binson2, L Hightow-Weidman3, C Richards-Clarke4, A Wohl5, A Outlaw6, T Giordano7, B Nyanthi8, and the Young MSM of Color SPNS Initiative Study Group

1George Washington Univ Sch of Publ Hlth and Hlth Svcs, Washington, DC, US; 2Ctr for AIDS Prevention Svcs, Univ of California, San Francisco, US; 3Univ of North Carolina at Chapel Hill, US; 4Bronx AIDS Svcs Inc and Children`s Hosp at Montefiore Med Ctr, NY, US; 5Los Angeles County Hlth Dept, CA, US; 6Horizons Project, Wayne State Univ, Detroit, MI, US; 7Baylor Coll of Med, Houston, TX, US; and 8AIDS Project East Bay, Oakland, CA, US

Title: A Validation Plan to Evaluate an Unmodified FDA-approved HIV RNA Assay Platform: A Comparison of Results Obtained Using the UltraSensitive Roche Amplicor® HIV-1 Monitor Test, v1.5 (Microwell Plate), the Roche COBAS® AmpliPrep/COBAS® TaqMan® Assay, and the Abbott RealTime HIV-1 Assay

Authors and Affiliations: Cheryl Jennings*1, D Brambilla2, S Granger3, S Fiscus4, J Nelson4, A Loftis4, R Kshatriya4, T Denny5, R Lovingood5, and J Bremer1

1Rush Med Coll, Chicago, IL, US; 2RTI, Rockville, MD, US; 3NERI, Watertown, MA, US; 4Univ of North Carolina at Chapel Hill, US; and 5Duke Univ, Durham, NC, US

Title: Safety and Effectiveness of Vaginal Microbicides BufferGel and 0.5% PRO 2000/5 Gel for the Prevention of HIV Infection in Women: Results of the HPTN 035 Trial

Authors and Affiliations: Salim Abdool Karim*1, A Coletti2, B Richardson3, G Ramjee4, I Hoffman5, M Chirenje6, T Taha7, M Kapina8, L Maslankowski9, and L Soto-Torres10

1Ctr for the AIDS Prgm of Res in South Africa, Durban; 2Family Hlth Intl, Medford, MA, US; 3Univ of Washington, Seattle, US; 4South African Med Res Council, Durban; 5Univ of North Carolina at Chapel Hill, US; 6Univ of Zimbabwe, Harare; 7Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US; 8Ctr for Infectious Disease in Zambia, Lusaka; 9Univ of Pennsylvania, Philadelphia, US; and 10NIAID, NIH, Bethesda, MD, US

Title: Determining the Genetic Linkage of HIV-1 Subtype B and C Transmission Pairs: Analyses of Viral env Sequences from Donor and Recipient

Authors and Affiliations: Jeffrey Anderson*1, B Keele2, J Salazar-Gonzalez2, L-H Ping1, L Arney1, C Williamson3, G Shaw2, B Hahn2, M Cohen1, R Swanstrom1, and CHAVI

1Univ of North Carolina at Chapel Hill, US; 2Univ of Alabama at Birmingham, US; and 3Inst of Infectious Disease and Molecular Med, Univ of Cape Town, South Africa

Title: Variability in the Pharmacokinetics of NRTI in TB/HIV Co-infected Ghanaian Patients

Authors and Affiliations: Awewura Kwara*1, M Lartey2, I Boamah2, N Rezk3, J Oliver-Commey4, E Kenu4, A Kashuba3, and M Court5

1Warren Alpert Med Sch, Brown Univ, Providence, RI, US; 2Univ of Ghana Med Sch, Accra; 3Univ of North Carolina at Chapel Hill, US; 4Korle-Bu Teaching Hosp, Accra, Ghana; and 5Tufts Univ Sch of Med, Boston, MA, US

Title: Performance of the Cavidi ExaVir Load Assay and the Ultra-sensitive p24 Antigen Assays Relative to the Roche Monitor HIV-1 RNA Assay: ACTG New Works Concept Sheet 227

Authors and Affiliations: P Stewart1, A Cachafeiro1, S Napravnik1, J Eron1, I Frank2, C Van Der Horst1, R Bosch3, D Bettendorf3, P Bohlin3, and Susan Fiscus*1

1Univ of North Carolina at Chapel Hill, US; 2Univ of Pennsylvania, Philadelphia, US; and 3Harvard Sch of Publ Hlth, Boston, MA, US

Title: Replication and Clonal Amplification of Compartmentalized HIV-1 Populations in the Cerebrospinal Fluid of Subjects with HIV-associated Dementia

Authors and Affiliations: Gretja Schnell*1, R Price2, S Spudich2, and R Swanstrom1

1Univ of North Carolina at Chapel Hill, US and 2San Francisco Gen Hosp, Univ of California, San Francisco, US

Title: Switching from Stable Lopinavir/Ritonavir-based to Raltegravir-based Combination ART Resulted in a Superior Lipid Profile at Week 12 but Did Not Demonstrate Non-Inferior Virologic Efficacy at Week 24

Authors and Affiliations: Joseph Eron*1, J Andrade2, R Zajdenverg3, C Workman4, D Cooper5, B Young6, X Xu7, B-Y Nguyen7, R Leavitt7, and P Sklar7

1Univ of North Carolina at Chapel Hill, US; 2Antinguo Hosp Civil de Guadalajara, Mexico; 3Hosp Escola Sao Francisco de Assis, Rio de Janeiro, Brazil; 4AIDS Res Initiative, Darlinghurst, Australia; 5Univ of New South Wales, Sydney, Australia; 6Denver Infectious Disease Consultants, CO, US; and 7Merck Res Labs, West Point, PA, US

Title: Addition of 7 Days of Zidovudine + Lamivudine to Peripartum Single-dose Nevirapine Effectively Reduces Nevirapine Resistance at 2 and 6 Weeks Post-partum in HIV-infected Mothers: Lilongwe, Malawi

Authors and Affiliations: S Farr1, J Nelson2, T Ng’ombe3, A Kashuba2, C Chasela3, A Kourtis1, J Johnson1, G Tegha3, J Wiener1, and Charles Van der Horst*2

1CDC, Atlanta, GA, US; 2Univ of North Carolina at Chapel Hill, US; and 3Univ of North Carolina Project, Lilongwe, Malawi

Title: Resting CD4+ T Cell Infection Is Limited by ART during Acute Infection, and Appears Correlated with Total Exposure to Viremia

Authors and Affiliations: N Archin1, D Parker1, A Sugarbaker1, J Kuruc1, C Hicks2, M McCauley3, M Cohen1, J Eron1, C Gay1, David Margolis*1, and for the NC STAT Prgm and the NIH CHAVI

1Univ of North Carolina at Chapel Hill, US; 2Duke Univ Sch of Med, Durham, NC, US; and 3Family Hlth Intl, Arlington, VA, US

Title: Differences in Risk Factors for Early and Late Losses to Follow-up in a Public HAART Clinic in South Africa

Authors and Affiliations: P Majuba1, D Westreich1,2, Mhairi Maskew*1, P MacPhail1, M Fox3,4, L Ngobeni1, T Seete1, A Van Rie1,2, I Sanne1, and Themba Lehtu Clinical Cohort

1Univ of the Witwatersrand, Johannesburg, South Africa; 2Univ of North Carolina at Chapel Hill, Gillings Sch of Global Publ Hlth, US; 3Ctr for Intl Hlth and Devt, Boston Univ, MA, US; and 4Hlth Economics Res Office, Johannesburg, South Africa

Title: Is the Placenta a Unique HIV-1 Subtype C Compartment?

Authors and Affiliations: Surender Kumar*1, D Janies1, V Mwapasa2, S Rogerson3, S Meshnick4, and J Kwiek1

1Ohio State Univ, Columbus, US; 2Univ of Malawi Coll of Med, Blantyre; 3Univ of Melbourne, Parkville, Australia; and 4Univ of North Carolina at Chapel Hill, US

Title: Comparison of 5 HIV Incidence Assays with the Less Sensitive Vironostika HIV Antibody Assay for Screening Subjects for A5217

Authors and Affiliations: Susan Fiscus*1, A Cachafeiro1, R Kshatriya1, S Napravnik1, M Owen2, S Keating3, M Busch3, S Little4, and C Hogan5,6

1Univ of North Carolina at Chapel Hill, US; 2CDC, Atlanta, GA, US; 3Blood Systems Res Inst, San Francisco, CA, US; 4Univ of California, San Diego, US; 5Columbia Univ, New York, NY, US; and 6Med Coll of Wisconsin, AIDS Resource Ctr of Wisconsin, Milwaukee, US

Title: Mortality and Virological Outcomes of 2105 HIV-infected Children Receiving ART in Soweto, South Africa

Authors and Affiliations: H Moultrie1, M Yotebieng2, L Kuhn3, and Tammy Meyers*1

1Harriet Shezi Children`s Clinic, Chris Hani Baragwanath Hosp, Univ of the Witwatersrand, Johannesburg, South Africa; 2Univ of North Carolina at Chapel Hill, US; and 3Columbia Univ, New York, NY, US

Title: Lopinavir/Ritonavir Concentrations in Breast Milk and Breast-feeding Infants

Authors and Affiliations: Amanda Corbett*1, F Martinson2, N Rezk1, A Kashuba1, D Jamieson3, C Chasela2, D Kayira2, G Tegha2, D Kamwendo2, C Van Der Horst1, and the BAN Study Team

1Univ of North Carolina at Chapel Hill, US; 2Univ of North Carolina Project, Lilongwe, Malawi; and 3CDC, Atlanta, GA, US

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