December 18, 2012 — A recently-published article by members of the Collaboratory of AIDS Researchers for Eradication at UNC discusses current strategies for treating latent HIV. Current antiretroviral therapy can bring HIV viral loads to undetectable levels, but a small amount of virus persists in reservoirs. These reservoirs of latent virus are the reason people cannot stop HIV treatment drugs. Lifelong therapy for millions of people is an unsustainable proposition, thus the need for curative therapies.
The current approaches to HIV latency are focused on either complete eradication (a total cure) or controlling the virus without antiretroviral therapy (a functional cure). The authors, Kirston Barton, Brandon Burch, Natalia Soriano-Sarabia and David Margolis, discuss the various strategies in detail and their potential for clinical development.
The article, “Prospects for Treatment of Latent HIV,” appears in the December 5 advance online issue of Clinical Pharmacology & Therapeutics.
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