Friday ID Conference: “A Novel Pediatric HIV-TB Combination Vaccine”

Title: Friday ID Conference: “A Novel Pediatric HIV-TB Combination Vaccine” – Kristina Abel, PhD
Date:
January 27, 2012
Time: 8:30 – 9:30 a.m.
Location: 1131 Bioinformatics (directions)

Kristina Abel, PhD

Description: The primary research focus of Abel’s lab is on host-pathogen interactions in infectious diseases. The lab is actively involved in HIV pathogenesis and vaccine studies using the nonhuman primate model of SIV infection in rhesus macaques. Together with collaborators at the Albert-Einstein College in New York, Abel and her team are currently testing a novel pediatric combination HIV-TB vaccine for immunogenicity and efficacy.

They are particularly interested in pediatric HIV transmission by breast-feeding and the early, local host immune responses. Not only are neonates and infants especially vulnerable to infectious diseases, but disease outcome is often more severe than in adults. Therefore, they are pursuing immunological studies to determine whether differences in TLR, TCR, and cytokine signaling between infants and adults contribute to altered host immune responses associated with increased disease severity in infants.

These studies are being performed with human and nonhuman primate samples. The knowledge gained could then be applied to pediatric vaccine design.

About Friday ID Conference

IGHID co-sponsors a weekly conference series which features distinguished clinicians and scientists from UNC, local universities, and other national and international institutions. The topics are varied and appeal to not only infectious disease specialists, but also professionals in epidemiology, public health, microbiology, biostatistics and other global health-related disciplines.

The conference takes place every Friday, September through June, from 8:30-9:30 a.m. in 1131 Bioinformatics (first floor auditorium) on the UNC campus. For more information, or to suggest a speaker, please contact the conference coordinator, Kathy James. To sign-up to receive weekly announcements of the conference, click here.

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Institute for Global Health & Infectious Diseases contact: Lisa Chensvold, (919) 843-5719, lisa_chensvold@med.unc.edu

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